Louisville Football to Face Ole Miss in Season Opener

Louisville Cardinals playing against Ole Miss Rebels at Nissan Stadium.

Nashville, Tennessee, December 11, 2025

The University of Louisville football team is scheduled to compete against Ole Miss in the 2026 season opener at Nissan Stadium in Nashville. This exciting neutral-site game coincides with Labor Day weekend, providing a prime opportunity for the Cardinals to showcase their talent on national television. Following a prior encounter in 2021, this matchup not only serves as a chance for redemption for Louisville fans but also reflects the team’s commitment to engaging with a growing local fan base and adapting to dynamic scheduling changes in college football.

Louisville Football to Face Ole Miss in 2026 Season Opener

Exciting Neutral-Site Matchup Set for Nashville

Louisville, Kentucky – The University of Louisville football team is gearing up for an electrifying start to the 2026 season with a neutral-site game against the University of Mississippi (Ole Miss) at Nissan Stadium in Nashville, Tennessee. Scheduled for Labor Day weekend, either September 5 or 6, 2026, the game will be nationally televised on ESPN, providing a platform for Louisville’s burgeoning football reputation.

This encounter marks the second meeting between the Cardinals and the Rebels, both of which have taken place at neutral sites. The initial clash occurred during the 2021 Chick-fil-A Kickoff Game in Atlanta, where Ole Miss emerged victorious with a score of 43-24. The upcoming match in Nashville is not only a chance for redemption for Louisville fans but also an opportunity for the team to showcase its talent on a national stage.

Impact of Scheduling Changes

The scheduling of this game follows the recent cancellation of a previously planned home-and-home series between Louisville and Georgia, originally set to begin in 2026. Georgia’s announcement prior to the SEC’s 2026 schedule release necessitated quick action to secure a competitive opponent, exemplifying the dynamic nature of college football scheduling.

Support from Athletic Administration

Louisville’s athletic director has expressed enthusiasm for this matchup, emphasizing the significance of showcasing Louisville football in a city with a strong local fan base. Such arrangements reflect a commitment to creating exciting experiences not just for players, but also for the fans who passionately support the program.

Nashville: A Familiar Venue for Louisville

Louisville fans may already feel a connection to Nissan Stadium, having witnessed their team play a neutral-site game against Western Kentucky at the venue during the 2019 season. This familiarity is expected to translate into strong fan support, adding to the lively atmosphere of the event.

What to Expect from the Game

With a seating capacity of approximately 69,000, Nissan Stadium is well-equipped to host a thrilling game. Anticipation is building among both Louisville and Ole Miss fans, eager to see their respective teams compete in a lively environment that has historically attracted significant crowds. The game promises to be a highlight of the college football calendar, drawing attention from across the nation.

Conclusion

The upcoming game against Ole Miss serves as a testament to Louisville’s resilience and ability to adapt in the face of unexpected challenges—an embodiment of the entrepreneurial spirit that drives not just the football program but the entire community. Fans and local businesses are encouraged to stay engaged as the date approaches and to support initiatives that celebrate Louisville’s thriving sports culture.

FAQ

  • When is the Louisville vs. Ole Miss game scheduled?

    The game is scheduled for Labor Day weekend, either September 5 or 6, 2026.

  • Where will the game be played?

    The game will be held at Nissan Stadium in Nashville, Tennessee.

  • What time will the game start?

    The exact kickoff time has not been finalized yet.

  • Which network will broadcast the game?

    The game will be nationally televised on ESPN.

  • Is this the first time Louisville and Ole Miss are playing each other?

    No, this is the second meeting between the two teams. The first was in the 2021 Chick-fil-A Kickoff Game in Atlanta, where Ole Miss won 43-24.

  • Why was this game scheduled?

    The game was added after the cancellation of a previously planned home-and-home series between Louisville and Georgia, which was set to begin in 2026.

  • Has Louisville played at Nissan Stadium before?

    Yes, Louisville played a neutral-site game against Western Kentucky at Nissan Stadium during the 2019 season.

  • Who is the athletic director of Louisville?

    Josh Heird is the athletic director of the University of Louisville.

  • What is the significance of this game for Louisville fans?

    The game provides an opportunity to showcase Louisville football on a national stage in a city with a strong Cardinals presence.

  • How can fans attend the game?

    Ticket information will be announced at a later date.

  • Will the game be available for viewing outside the United States?

    Broadcast details for international viewers have not been specified yet.

  • Are there any other notable games in Louisville’s 2026 schedule?

    Details about the complete 2026 schedule will be released at a later date.

  • How can fans stay updated on game details?

    Fans can stay updated by following official announcements from the University of Louisville athletics department and checking the university’s official website.

  • Will there be any special events surrounding the game?

    Information about special events will be provided closer to the game date.

  • Is there a history of Louisville playing in Nashville?

    Yes, Louisville has previously played a neutral-site game against Western Kentucky at Nissan Stadium during the 2019 season.

  • What is the capacity of Nissan Stadium?

    Nissan Stadium has a seating capacity of approximately 69,000.

  • Will the game be available for streaming online?

    Streaming details will be provided closer to the game date.

  • Are there any travel packages available for fans?

    Information about travel packages will be available closer to the game date.

  • Will there be any fan events in Nashville during the game weekend?

    Details about fan events will be announced closer to the game date.

  • Is there a rivalry between Louisville and Ole Miss?

    While not a traditional rivalry, this matchup adds an exciting non-conference game to both teams’ schedules.

  • What is the significance of the game for Ole Miss fans?

    The game offers Ole Miss fans the opportunity to see their team play in a neutral-site game against a strong opponent.

  • Will there be any special promotions for the game?

    Information about special promotions will be provided closer to the game date.

  • What is the significance of the game for Nashville?

    The game brings a high-profile college football matchup to Nashville, showcasing the city’s appeal as a destination for major sporting events.

Feature Details
Opponent University of Mississippi (Ole Miss)
Game Date September 5 or 6, 2026
Location Nissan Stadium, Nashville, Tennessee
TV Broadcast ESPN
Previous Meeting 2021 Chick-fil-A Kickoff Game
Nissan Stadium Capacity Approximately 69,000

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